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SN2 Palmitate
SN2 Palmitate is a structured triglyceride where palmitic acid bonded to the middle position (sn-2) of the glycerol backbone. Structured triglycerides are achieved through an enzymatic process using vegetable oils. Current usage of structured triglycerides is mainly for infant formula providing human milk fat substitute.
== SN2 Palmitate in human milk ==
Fats in human breast milk provides about 50% of energy needed for the development and growth newborn infant. About 98% of the fats provided by the human milk are in the form of triglycerides, which themselves are molecules consisting of mixtures of three fatty acids bonded to sn-1, sn-2, and sn-3 positions of a glycerol backbone.〔Giovannini, M., E. Riva, and C. Agostoni, Fatty acids in pediatric nutrition. Pediatr Clin North Am, 1995. 42(4): p. 861-77.〕
The human mammary gland provides the baby with a unique fat composition where the fatty acids arranged in specific combinations, different from the triglycerides in other human tissues and plasma,〔Breckenridge, W.C., L. Marai, and A. Kuksis, Triglyceride structure of human milk fat. Can J Biochem, 1969. 47(8): p. 761-9.〕 or from common dietary fats and oils. Palmitic acid (C16:0) is the major saturated fatty acid in human milk, accounting for 17-25% of the total fatty acids,〔 with over 70% of 16:0 is esterified at the milk triglyceride sn-2 position.〔〔Jensen, R.G., Lipids in human milk. LIPIDS, 1999. 34(12): p. 1243-71.〕 The major unsaturated fatty acid in human milk is oleic acid (18:1n-9) and this is mostly esterified at the triglyceride sn-1,3 (outer) positions. The positioning of palmitic acid at the sn-2 position is conserved in all women, regardless of race or nutrition, unlike the general fatty acid profile of human milk.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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